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-synuclein, which is a main ingredient of Lewy bodies, in PARK one in 1997 and parkin in PARK 2 in 1998, that is an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) worry, counsel that dysfunction of your intracellular proteinase techniques, such as ubiquitin-proteasome process or lysosomal technique, which eliminates unwanted harmful prot